This information is take directly from the manufacturers (Sweet cures) web pages and is presented here for personal information only;
The effectiveness of D-Mannose when used to combat an E. coli infection varies from person to person depending on weight, severity of infection and other biological factors such as gut health, ability to absorb the D-Mannose through the small intestine and pre-existing conditions such as Crohn's disease or SIBO. D-Mannose tablets can be taken with water or your favorite beverage, the powder can also be mixed into your favorite beverage. Avoid urine acidifying beverages such as cranberry juice and alcohol.
For rapid relief, ingest three grams of pure D-Mannose with a glass of water every 3 hours, day and night for the first 48 hours. Do not skip the night doses, set your alarm. Gradually reduce frequency over the next few days as symptoms improve. Reduce to prophylactic dose, 2 grams daily, once symptoms have completely subsided.
You may experience 2-3 more flare ups before all embedded bacteria have been removed and your propensity for attacks diminishes. If the infection has reached the kidneys (you may feel lower back pain, sick or have a fever), see your Doctor immediately.
To help prevent recurrence, ingest two grams of pure D-Mannose with a glass of water once a day. This Randomized Clinical Trial has demonstrated a 2 gram daily dose of pure D-Mannose prevented recurrence of acute cystitis in 85.4% of women with a history of recurrent UTI, perfoming 4 times better than the prescribed antibiotic.
Take 3 grams of Waterfall D-Mannose one hour before intimacy. Refrain from urinating.
Urinate immediately afterwards, then take another 3 grams.
For the next 48 hours take 3 grams every 4 - 6 hours.
Maintain normal hygiene standards.
Maintain this protocol around intimacy for a few months.
Gradually, you should begin to see improvement.
Waterfall D-Mannose is as effective for men as it is for women. Men with a propensity for cystitis may find it beneficial to urinate after being intimate.
Cystitis problems in men may be an indication of a more serious problem such as a prostate condition, and should be thoroughly investigated by a Doctor. For more information, please see our page on Male Urinary Problems.
For best results, or stubborn infections
Anecdotal evidence and customer feedback suggests the following practices substantially increase effectiveness:
An hour after ingesting D-Mannose with a glass of water, if possible, drink another glass or two of water. This will help flush the E. coli bacteria, which has attached to the D-Mannose, from your system and clear the urinary tract of bacteria.
Continue to use prophylactically even after symptoms has subsided. Bacteria embed themselves deep in the bladder wall when escaping attack from D-Mannose and may lay dormant behind biofilms until conditions are favourable.
Remember, D-Mannose is simply a sugar which is not metabolized. It passes through your urinary system, attaching to bacteria, and is then expelled through urine. This makes it safe to use with children as well as diabetics.
Keep the urine's pH at or above 7 during the course of your D-Mannose regimen. Bacteria thrive in an acidic environment doubling in numbers every 20 - 40 minutes. Conversely, bacterial growth is inhibited in a more alkaline environment.
Pregnant Women, Children, Babies, and Pets
Unlike medications such as antibiotics which are classed as chemical substances, D-Mannose is a completely natural simple sugar, classed as a food supplement.
D-Mannose will cross the placental barrier, but is most unlikely to cause any damage to the foetus, just as a spoonful of regular table sugar would not. Research shows that the unborn baby requires D-Mannose, which is naturally produced by the human body, for normal development. If you are pregnant we strongly recommend that you consult a medical professional before taking the D-Mannose or any other supplement.
For children, babies, and pets, the dose should be adjusted according to proportion of adult human weight, and the amount of fluids they drink.
The dose of D-Mannose for catheterised people, men or women, generally needs to be higher than the dose for people who do not catheterise. The actual amount you need to take is best found best by trial and error. Begin with the recommended adult or child dose, and gradually increase daily if necessary.
Urethral infections may take longer to subside because D-Mannose rapidly passes through the urethra when you urinate, rather than lingering as it does in the bladder. To increase effectiveness, you might want to try a method recommended by Doctors when a mid-stream urine sample is required: when your bladder is almost empty and there's little pressure remaining behind the flow, with a clean palm, press up against the urethra using just enough pressure to moderate the flow, until your bladder is completely emptied. You can repeat this each time you urinate with D-Mannose in your system.
This method provides the D-Mannose with a little extra time to detach the bacteria from your urethral wall. It can take anywhere from one to seven days to clear urethral symptoms. Contracting your muscles, sometimes referred to as 'bladder control', is not as effective as the palm pressure method as your urethra would not be full of urine.
Remember cystitis-like symptoms may be caused by other problems such as blockages, bladder stones, prostate problems, failing kidneys, STDs and viral or fungal infections. Please see your Doctor if symptoms persist.
Always consult a doctor if you have a health problem or are considering taking any supplement alongside prescription drugs.
Always replace the lid tightly.
Use by Best Before End date.
Side Effects & Cautionary information
Potential for exacerbation of symptoms in sufferers of Small Intestinal Bacterial Overgrowth (SIBO)
When taken in high doses, may cause bloating, loose stools or diarrhea.
Diabetics should monitor blood sugar levels closely.
Please see D-Mannose Side Effects for more detailed information.
D-Mannose Side Effects
It is very important to ask questions about any supplement and its potential effects, D-Mannose is no exception. D-Mannose is recommended by the National Institute for Health and Care Excellence and doctors and chemists. As a food supplement, it creates no bacterial resistance and has no damaging side-effects, and can be safely used as a maintenance product daily.
For nearly 70 years research has shown positive effects of D-Mannose on E. coli, the bacterium that accounts for 85-90% of Urinary Tract and Bladder Infections. Research papers and reports on D-Mannose and its symbiotic, Velcro like relationship with E. coli and evidence of how effective D-Mannose is at attaching to, and flushing bacteria out of the bladder are freely available online from credible sources such as the British Medical Journal
D-Mannose is a monosaccharide related to glucosamine that attaches to bacteria and then leaves the body when we urinate. D-Mannose uses the bacteria's best weapon against them. Microscopic fimbrial hairs produced by bacteria to attach to the D-Mannose naturally present in the bladder, attach like Velcro to the ingested D-Mannose in the urine. Once the fimbrial receptors are filled they helplessly float in the urine and are flushed away down the toilet. They can never become resistant.
Antibiotics are now known to radically change the gastrointestinal bacterial populations required for good health, potentially causing fungal or bacterial infections, that is why doctors are suggesting we use antibiotics sparingly. Whereas D-Mannose does nothing other than remove 'bad' bacteria by process of attachment and voiding, without harmful side effects.
However, always play it safe and monitor:
Quality. It is very important to check the quality of mannose you are buying. No chemical residues, no additives and a guaranteed 99% purity are all essential safety features.
Symptoms. Keep a close eye on your symptoms. Use urine test strips to monitor nitrites, leukocytes and blood. If D-Mannose is not alleviating your symptoms, seek medical help as a bacterium other than E. coli may be present and could develop in to kidney infection.
SIBO. Small Intestinal Bacterial Overgrowth experts recommend avoiding D-Mannose while others say it is tolerated fairly well. A potential for exacerbation does exist, if you are affected, adjust the dose.
D-Mannose is an isomer of glucose, not glucose, so is not metabolised to any discernible extent. It is a food supplement and not a drug. It is widely considered to be safer than white table sugar. In over 70 years of use, there have never been any teratogenic effects shown. There are a couple of points to bear in mind:
D-Mannose is a rare sugar already present in almost every cell in the human body, we create it from glucose. Ingesting large amounts of D-Mannose may cause diahorrhea (and sometimes minor nausea), because it flushes pathological E. coli out of the colon under these circumstances. It's probably best to stick to a dose level that can more easily be absorbed.
Always follow medical advice during pregnancy.
Gas and Bloating
Gas or Bloating may be experienced by people when they first use D-Mannose. The most likely culprit is Leaky Gut and when the gut is restored to health, this problem usually resolves itself. In the meantime, taking D-Mannose with food and probiotics has been reported to help.
Conditions commonly associated with dysbiosis (an imbalance or good and bad bacteria in the gut) are asthma, food allergies, sinusitis, eczema, migraine, irritable bowel, candida overgrowth, obesity, fibromyalgia, and inflammatory disorders such as arthritis, fibroids and PMT. Overuse of antibiotics, anti-inflammatory drugs, poor diet and lack of exercise are seen as equally damaging to gut health.