Anal Anti-Itch Spray Assuage perianal anti-itch spray brings fast, long-lasting relief for pruritus ani, or anal itching, and it aids in protecting irritated anorectal areas. Judging from the emails from my customers, there just aren't many effective medications for the specific treatment of anal itching on the market. Most people, and some doctors, don't realize the terrible suffering anal itching can cause. I have received many testimonials from customers who suffered for years before they tried Assuage. The upside-down spray applicator protects the remedy from contamination, and allows easy application. Natural Assuage does not contain anesthetics, antihistamines, hydrocortisone which may cause problems with extended use.